Influence of cyclosporin A on radiological progression in early rheumatoid arthritis patients: a 42-month prospective study
Identifieur interne : 002524 ( Main/Exploration ); précédent : 002523; suivant : 002525Influence of cyclosporin A on radiological progression in early rheumatoid arthritis patients: a 42-month prospective study
Auteurs : A. A. Drosos ; P. V. Voulgari ; A. Katsaraki ; A. K. ZikouSource :
- Rheumatology International [ 0172-8172 ] ; 2000-03-01.
English descriptors
Abstract
Abstract: The aim of this study was to evaluate whether cyclosporin A (CsA) influences the radiological disease progression in early rheumatoid arthritis (RA) patients in comparison with other disease-modifying drugs (DMARDs). A total of 103 early RA patients, without prior use of DMARDs, were randomized to receive CsA (3 mg/kg per day) or methotrexate (MTX) (0.15 mg/kg per week). In addition, all patients received prednisone (7.5 mg/day). After 42 months of treatment, pairs of hand and wrist radiographs of 41 patients treated with CsA and 42 treated with MTX were evaluated blindly and separately by two investigators, using reference radiographs for scoring. A scale scoring similar to Larsen's standard radiographs with minor modifications was used. The studied radiographs were obtained at the beginning and 42 months after therapy in both groups. Patients in both groups responded beneficially to the above treatment regimens. In the CsA group, 37 patients (71%) remained radiographically stable and 4 worsened, while in the MTX group 39 patients (76%) remained stable and 3 deteriorated. No significant radiological worsening was found in the CsA-treated patients as compared to those treated with MTX. Early immunointervention in RA patients appears to be crucial for the future development of joint damage. CsA can delay radiological disease progression and may inhibit joint damage deterioration in early RA patients.
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DOI: 10.1007/s002960050113
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A." last="Drosos">A. A. Drosos</name><affiliation><wicri:noCountry code="subField">GR</wicri:noCountry></affiliation></author><author><name sortKey="Voulgari, P V" sort="Voulgari, P V" uniqKey="Voulgari P" first="P. V." last="Voulgari">P. V. Voulgari</name><affiliation><wicri:noCountry code="subField">GR</wicri:noCountry></affiliation></author><author><name sortKey="Katsaraki, A" sort="Katsaraki, A" uniqKey="Katsaraki A" first="A." last="Katsaraki">A. Katsaraki</name><affiliation><wicri:noCountry code="subField">GR</wicri:noCountry></affiliation></author><author><name sortKey="Zikou, A K" sort="Zikou, A K" uniqKey="Zikou A" first="A. K." last="Zikou">A. K. Zikou</name><affiliation><wicri:noCountry code="subField">GR</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Rheumatology International</title><title level="j" type="sub">Clinical and Experimental Investigations</title><title level="j" type="abbrev">Rheumatology International</title><idno type="ISSN">0172-8172</idno><idno type="eISSN">1437-160X</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="2000-03-01">2000-03-01</date><biblScope unit="volume">19</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="113">113</biblScope><biblScope unit="page" to="118">118</biblScope></imprint><idno type="ISSN">0172-8172</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0172-8172</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cyclosporin A</term><term>Key words Early rheumatoid arthritis</term><term>Methotrexate</term><term>Radiological progression</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The aim of this study was to evaluate whether cyclosporin A (CsA) influences the radiological disease progression in early rheumatoid arthritis (RA) patients in comparison with other disease-modifying drugs (DMARDs). A total of 103 early RA patients, without prior use of DMARDs, were randomized to receive CsA (3 mg/kg per day) or methotrexate (MTX) (0.15 mg/kg per week). In addition, all patients received prednisone (7.5 mg/day). After 42 months of treatment, pairs of hand and wrist radiographs of 41 patients treated with CsA and 42 treated with MTX were evaluated blindly and separately by two investigators, using reference radiographs for scoring. A scale scoring similar to Larsen's standard radiographs with minor modifications was used. The studied radiographs were obtained at the beginning and 42 months after therapy in both groups. Patients in both groups responded beneficially to the above treatment regimens. In the CsA group, 37 patients (71%) remained radiographically stable and 4 worsened, while in the MTX group 39 patients (76%) remained stable and 3 deteriorated. No significant radiological worsening was found in the CsA-treated patients as compared to those treated with MTX. Early immunointervention in RA patients appears to be crucial for the future development of joint damage. CsA can delay radiological disease progression and may inhibit joint damage deterioration in early RA patients.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Drosos, A A" sort="Drosos, A A" uniqKey="Drosos A" first="A. A." last="Drosos">A. A. Drosos</name><name sortKey="Katsaraki, A" sort="Katsaraki, A" uniqKey="Katsaraki A" first="A." last="Katsaraki">A. Katsaraki</name><name sortKey="Voulgari, P V" sort="Voulgari, P V" uniqKey="Voulgari P" first="P. V." last="Voulgari">P. V. Voulgari</name><name sortKey="Zikou, A K" sort="Zikou, A K" uniqKey="Zikou A" first="A. K." last="Zikou">A. K. Zikou</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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